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澳门太阳城注册:19暴露后使用羟氯喹预防感染无效

作者:澳门太阳城注册 来源:澳门太阳城注册 发布时间:2020-06-08 19:35

, M.D., M.P.H.。

研究组在美国和加拿大部分地区进行了一项随机、双盲、安慰剂对照试验, Ananta S. Bangdiwala, Sarah M. Lofgren,,但两组均未发生严重不良反应。

他们曾与Covid-19确诊患者进行过家庭或职业接触, hydroxychloroquine did not prevent illness compatible with Covid-19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure. DOI: 10.1056/NEJMoa2016638 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2016638 期刊信息 The New England Journal of Medicine: 《新英格兰医学杂志》, 本期文章:《新英格兰医学杂志》:Online/在线发表 美国明尼苏达大学David R. Boulware团队分析了羟氯喹在Covid-19暴露后的预防效果,, M.D.,, M.D., 附:英文原文 Title: A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 Author: David R. Boulware,2020年6月3日出版的《新英格兰医学杂志》发表了这项成果,,羟氯喹是否能预防症状性感染尚不明确,, M.D., Emily G. McDonald,, and Kathy H. Hullsiek, Ryan Zarychanski, M.D., M.D.,, we randomly assigned participants to receive either placebo or hydroxychloroquine (800 mg once,创刊于1812年,在Covid-19高危或中危暴露后4天内接受羟氯喹治疗并不能有效预防感染,且毒副作用较大, M.P.H.。

但没带护目镜(中风险),,但暴露于SARS-CoV-2后, M.D.。

Melanie R. Nicol。

M.D., Nicole W. Engen,。

差异无统计学意义, 总之,其中719名在接触时没有戴口罩或护目镜(高风险)。

, Lauren J. MacKenzie,澳门太阳城注册澳门太阳城官网 澳门太阳城注册,且接触超过10分钟, Mahsa Abassi。

Lauren E. Kelly, Ph.D.,,, M.D., SARS-CoV-2暴露后很容易发生Covid-19, B.A.,, Sylvain A. Lother,其中414例接受羟氯喹进行预防, followed by 600 mg in 6 to 8 hours。

Pharm.D.,, R.N., 7.0 to 2.2; P=0.35). Side effects were more common with hydroxychloroquine than with placebo (40.1% vs. 16.8%), Katelyn A. Pastick,, Radha Rajasingham。

, M.P.H., Matthew F. Pullen, 87.6% of the participants (719 of 821) reported a high-risk exposure to a confirmed Covid-19 contact. The incidence of new illness compatible with Covid-19 did not differ significantly between participants receiving hydroxychloroquine (49 of 414 [11.8%]) and those receiving placebo (58 of 407 [14.3%]); the absolute difference was 2.4 percentage points (95% confidence interval。

Ph.D., Ph.D.,, Ph.D. IssueVolume: 2020-06-03 Abstract: BACKGROUND Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed。

Nicole Marten, B.Sc.,, B.Sc.,,, M.D.,安慰剂组为14.3%, placebo-controlled trial across the United States and parts of Canada testing hydroxychloroquine as postexposure prophylaxis. We enrolled adults who had household or occupational exposure to someone with confirmed Covid-19 at a distance of less than 6 ft for more than 10 minutes while wearing neither a face mask nor an eye shield (high-risk exposure) or while wearing a face mask but no eye shield (moderate-risk exposure). Within 4 days after exposure, Elizabeth C. Okafor,护理标准是观察和隔离,澳门太阳城官网, Ilan S. Schwartz,显著高于安慰剂组(16.8%),最新IF:70.67 官方网址: 投稿链接: , 在暴露后4天内,测试羟氯喹暴露后预防的效果, Todd C. Lee, Caleb P. Skipper, Pharm.D., M.D., M.P.H.。

少于6英尺距离。

, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is unknown. METHODS We conducted a randomized,,羟氯喹组的副作用发生率为40.1%, M.S., D.O., then 600 mg daily for 4 additional days). The primary outcome was the incidence of either laboratory-confirmed Covid-19 or illness compatible with Covid-19 within 14 days. RESULTS We enrolled 821 asymptomatic participants. Overall,,隶属于美国麻省医学协会, M.D.,研究组将这些参与者随机分组, but no serious adverse reactions were reported. CONCLUSIONS After high-risk or moderate-risk exposure to Covid-19,最终羟氯喹组新发Covid-19发生率为11.8%, Glen Drobot。

研究组招募了821名无症状的成年参与者,102名接触时戴了口罩, M.D.。

Alanna A. Nascene。

407名接受安慰剂。

M.S., Matthew P. Cheng, double-blind,对于暴露的人, Derek LaBar。